BUB3

Across TCGA patient cohorts, BUB3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BUB3-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and GATA6. Each is linked with BUB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BUB3-to-partner and partner-to-BUB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by BUB3-low versus BUB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB3→partner) and Y-score (partner→BUB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.120	-3.558	.001	.002	3	1
UCEC	eIF4G →	+0.253	+2.000	.033	.030	3	1
UCEC	GATA6 →	-0.144	-3.155	.017	.018	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.438	+2.009	.007	.017	3	1
UCEC	Heregulin →	-0.128	-1.861	.007	.049	3	1
UCEC	HSP70 →	-0.346	-3.449	.025	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

14-3-3_beta by BUB3 expression — UCEC

Explore this box plot interactively →