BUB3

Across TCGA cell cohorts, BUB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,608 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BUB3-associated GO terms across cancer lineages are Nuclear division, Spindle elongation, and Double-strand break repair. Each is linked with BUB3 in more than 17 cancer types. Because this analysis shows association rather than direction, both BUB3-to-partner and partner-to-BUB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear division grouped by BUB3-low versus BUB3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB3→partner) and Y-score (partner→BUB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Nuclear division →	+0.097	+1.122	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Spindle elongation →	+0.305	+1.218	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair →	+0.061	+0.868	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome organization →	+0.123	+1.145	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Mitotic sister chromatid segregation →	+0.139	+1.132	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Sister chromatid segregation →	+0.138	+1.132	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,608 associations by consensus.

Nuclear division by BUB3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →