BUB3

Across TCGA cell cohorts, BUB3 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BUB3-associated genes across cancer lineages are ZNF831, SCN2A, and LHCGR. Each is linked with BUB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BUB3-to-partner and partner-to-BUB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by BUB3-low versus BUB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB3→partner) and Y-score (partner→BUB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.014	+3.103	<.001	.004	3	1
LARGE_INTESTINE	SCN2A →	+0.540	+3.658	<.001	.003	3	1
LARGE_INTESTINE	LHCGR →	+0.029	+3.297	.002	.002	3	1
LARGE_INTESTINE	VAX1 →	+0.646	+3.519	.001	.007	3	1
LARGE_INTESTINE	CLEC14A →	+0.026	+3.115	<.001	.004	3	1
LARGE_INTESTINE	LCN8 →	+0.140	+3.125	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ZNF831 by BUB3 expression — LARGE_INTESTINE

Explore this box plot interactively →