BUB1

Across TCGA patient cohorts, BUB1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BUB1-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and 14-3-3_beta. Each is linked with BUB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BUB1-to-partner and partner-to-BUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BUB1-low versus BUB1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB1→partner) and Y-score (partner→BUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.453	+3.178	<.001	.010	1	5
COAD	C-Raf →	+0.276	+3.178	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.078	-1.973	.023	.029	3	2
UCEC	Chk2_pT68 →	-0.134	-3.143	.035	.018	3	2
UCEC	4E-BP1 →	+0.244	+2.700	.008	.005	3	2
COAD	MIG-6 →	+0.121	+3.229	.013	.009	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by BUB1 expression — COAD

Explore this box plot interactively →