BUB1

Across TCGA cell cohorts, BUB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,529 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BUB1-associated GO terms across cancer lineages are Mitotic nuclear division, Positive regulation of cell cycle, and Meiotic sister chromatid cohesion. Each is linked with BUB1 in more than 19 cancer types. Because this analysis shows association rather than direction, both BUB1-to-partner and partner-to-BUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic nuclear division grouped by BUB1-low versus BUB1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB1→partner) and Y-score (partner→BUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Mitotic nuclear division →	+0.146	+1.332	<.001	.002	3	20
OESOPHAGUS	Positive regulation of cell cycle →	+0.103	+1.357	<.001	.001	3	20
OESOPHAGUS	Meiotic sister chromatid cohesion →	+0.240	+1.488	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Spindle elongation →	+0.235	+1.335	<.001	.001	3	20
LUNG_NSCLC_LUSC	Spindle midzone assembly →	+0.227	+1.286	<.001	.001	3	20
LUNG_NSCLC_LUSC	Mitotic spindle midzone assembly →	+0.312	+1.649	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,529 associations by consensus.

Mitotic nuclear division by BUB1 expression — OESOPHAGUS

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