BUB1

Across TCGA cell cohorts, BUB1 mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BUB1-associated genes across cancer lineages are GSK2801, AGI-6780, and 123829. Each is linked with BUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BUB1-to-partner and partner-to-BUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK2801 grouped by BUB1-low versus BUB1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BUB1→partner) and Y-score (partner→BUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK2801 →	+0.362	+2.871	.015	.021	3	1
LARGE_INTESTINE	AGI-6780 →	+0.385	+2.868	.036	.022	3	1
LARGE_INTESTINE	123829 →	+0.649	+2.871	.018	.021	3	1
LARGE_INTESTINE	OF-1 →	+0.319	+2.868	.019	.022	2	2
LARGE_INTESTINE	Quizartinib →	+0.358	+2.874	.018	.021	2	2
LARGE_INTESTINE	WYE-125132 →	+0.616	+2.874	.010	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GSK2801 by BUB1 expression — LARGE_INTESTINE

Explore this box plot interactively →