BTRC

Across TCGA patient cohorts, BTRC mutation is significantly associated with the RNA expression of many other genes, with 1,461 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTRC-associated genes across cancer lineages are RN7SL789P, PRPF4, and NDUFB6. Each is linked with BTRC in more than 2 cancer types. Because this analysis shows association rather than direction, both BTRC-to-partner and partner-to-BTRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL789P grouped by BTRC-low versus BTRC-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTRC→partner) and Y-score (partner→BTRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RN7SL789P →	+0.179	+4.733	<.001	.003	3	3
UCEC	PRPF4 →	+0.400	+2.627	.007	.005	3	3
UCEC	NDUFB6 →	+0.402	+3.595	.004	.001	3	3
COAD	PPP2CA →	+0.615	+3.223	<.001	.009	3	2
COAD	RPA1 →	+0.610	+3.230	<.001	.009	3	2
COAD	MBD2 →	+0.481	+3.210	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,461 associations by consensus.

RN7SL789P by BTRC expression — LIHC

Explore this box plot interactively →