BTRC

Across TCGA cell cohorts, BTRC mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BTRC-associated genes across cancer lineages are IFNA21, UNCX, and UTF1. Each is linked with BTRC in more than 1 cancer types. Because this analysis shows association rather than direction, both BTRC-to-partner and partner-to-BTRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA21 grouped by BTRC-low versus BTRC-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTRC→partner) and Y-score (partner→BTRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IFNA21 →	+0.043	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	UNCX →	+0.126	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	UTF1 →	+0.597	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	DAOA →	+0.017	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR10G7 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	SSX7 →	+0.017	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

IFNA21 by BTRC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →