BTNL3

Across TCGA patient cohorts, BTNL3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTNL3-associated genes across cancer lineages are HER3_pY1289, c-Met_pY1235, and DJ-1. Each is linked with BTNL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTNL3-to-partner and partner-to-BTNL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by BTNL3-low versus BTNL3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTNL3→partner) and Y-score (partner→BTNL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER3_pY1289 →	-0.093	-2.321	.028	.033	3	1
SKCM	c-Met_pY1235 →	-0.083	-3.169	.027	.017	3	1
SKCM	DJ-1 →	+0.232	+3.459	.004	.005	3	1
UCEC	EGFR_pY1068 →	-0.262	-3.459	.007	.005	3	1
UCEC	A-Raf_pS299 →	-0.100	-3.000	.032	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.171	-2.807	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

HER3_pY1289 by BTNL3 expression — SKCM

Explore this box plot interactively →