BTN3A3

Across TCGA patient cohorts, BTN3A3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTN3A3-associated genes across cancer lineages are Caspase-8, CD49b, and 14-3-3_beta. Each is linked with BTN3A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTN3A3-to-partner and partner-to-BTN3A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by BTN3A3-low versus BTN3A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTN3A3→partner) and Y-score (partner→BTN3A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.231	-1.973	.022	.029	3	2
UCEC	CD49b →	-0.278	-2.308	.015	.033	3	2
UCEC	14-3-3_beta →	-0.130	-3.074	.001	<.001	3	1
UCEC	eIF4E →	+0.173	+3.087	.042	<.001	3	1
UCEC	ACC_pS79 →	+0.282	+1.906	.043	.016	3	1
UCEC	MEK1 →	+0.415	+2.415	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Caspase-8 by BTN3A3 expression — UCEC

Explore this box plot interactively →