BTN3A3

Across TCGA cell cohorts, BTN3A3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BTN3A3-associated genes across cancer lineages are HCN4, GYPE, and GSG1L2. Each is linked with BTN3A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTN3A3-to-partner and partner-to-BTN3A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HCN4 grouped by BTN3A3-low versus BTN3A3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTN3A3→partner) and Y-score (partner→BTN3A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HCN4 →	+0.246	+3.678	<.001	.002	3	1
LARGE_INTESTINE	GYPE →	+0.013	+2.878	.001	.009	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	RSC1A1 →	+1.092	+3.782	<.001	.002	3	1
BLOOD_Leukemia	PMP2 →	+0.048	+3.847	<.001	.004	3	1
BLOOD_Leukemia	KLK15 →	+0.446	+4.091	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

HCN4 by BTN3A3 expression — LARGE_INTESTINE

Explore this box plot interactively →