BTN3A1

Across TCGA pan-cancer cohorts, BTN3A1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BTN3A1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher BTN3A1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BTN3A1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where BTN3A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.525	1.000	<.001	27	view →
HNSC	DFS	Median	All	1.000	0.177	.024	21	view →
PDAC	OS	Quartile	All	0.300	1.000	.038	18	view →
UCEC	DFS	Quartile	All	0.777	1.000	.029	4	view →
LUAD	DFS	Tertile	III,IV	0.693	0.333	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BTN3A1–LSCC (DFS)

Open the LSCC breakdown →