BTN2A2

Across TCGA pan-cancer cohorts, BTN2A2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BTN2A2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BTN2A2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BTN2A2 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, KIRP, and HNSC are the cancer types where BTN2A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BTN2A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.292	<.001	12	view →
KIRP	Male	II,III,IV	+0.980	<.001	11	view →
HNSC	All	III,IV	+0.649	<.001	10	view →
LIHC	All	III,IV	+0.975	<.001	9	view →
LUAD	Male	II,III,IV	−0.659	<.001	9	view →
LUSC	All	II,III,IV	−0.899	<.001	8	view →
KICH	Female	All	−0.884	<.001	7	view →
STAD	All	II,III,IV	+0.816	.001	7	view →
CHOL	All	All	+2.121	<.001	3	view →
ESCA	All	All	+1.068	.002	3	view →
COAD	All	All	+0.242	.027	2	view →
PRAD	All	All	−0.240	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BTN2A2–KIRC

Open the KIRC breakdown →