BTN2A1

Across TCGA pan-cancer cohorts, BTN2A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BTN2A1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BTN2A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BTN2A1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where BTN2A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BTN2A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.850	<.001	12	view →
KIRC	Female	All	+0.880	<.001	11	view →
LIHC	Female	II,III,IV	+1.166	<.001	9	view →
KICH	Female	II,III,IV	−1.254	<.001	8	view →
STAD	Male	II,III,IV	+0.944	<.001	8	view →
LUSC	All	All	−0.540	<.001	8	view →
CHOL	Female	All	+2.863	<.001	5	view →
COAD	All	All	+0.251	.007	5	view →
BRCA	Female	All	−0.262	<.001	4	view →
ESCA	All	All	+1.018	.004	3	view →
PRAD	All	All	−0.590	<.001	2	view →
UCEC	All	All	−0.488	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BTN2A1–HNSC

Open the HNSC breakdown →