Across TCGA pan-cancer cohorts, BTLA mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of BTLA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where BTLA mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types BTLA is over-expressed in tumor.

LUAD and LSCC are the cancer types where BTLA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BTLA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.477	.001	3	view →
LSCC	All	All	+0.339	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: BTLA RNA expression & survival · all BTLA data types