BTK

Across TCGA pan-cancer cohorts, BTK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BTK data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher BTK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BTK expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

COAD, LUAD, and GBM are the cancer types where BTK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.932	1.000	.025	60	view →
LUAD	DFS	Quartile	All	0.867	0.472	.009	4	view →
GBM	OS	Quartile	All	0.353	0.572	.024	4	view →
HNSC	DFS	Tertile	II,III,IV	0.898	1.000	.011	4	view →
CCRCC	DFS	Median	III,IV	0.763	0.947	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BTK–COAD (DFS)

Open the COAD breakdown →