BTK

Across TCGA patient cohorts, BTK mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTK-associated genes across cancer lineages are eIF4E, Chk1, and Bad_pS112. Each is linked with BTK in more than 2 cancer types. Because this analysis shows association rather than direction, both BTK-to-partner and partner-to-BTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by BTK-low versus BTK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTK→partner) and Y-score (partner→BTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.213	+2.832	.030	.035	3	3
SKCM	Chk1 →	+0.181	+2.186	.029	.032	3	3
LUSC	Bad_pS112 →	+0.199	+3.321	.006	.009	3	2
COAD	PCNA →	+0.401	+2.815	.003	.036	3	2
UCEC	FoxM1 →	+0.197	+2.584	.012	.010	3	2
UCEC	INPP4B →	-0.240	-2.662	.015	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by BTK expression — COAD

Explore this box plot interactively →