BTK

Across TCGA cell cohorts, BTK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,180 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BTK-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with BTK in more than 8 cancer types. Because this analysis shows association rather than direction, both BTK-to-partner and partner-to-BTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by BTK-low versus BTK-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BTK→partner) and Y-score (partner→BTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.121	+0.421	<.001	.002	3	9
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.141	+0.446	<.001	.001	3	9
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.138	+0.424	<.001	.002	3	9
BLOOD_Lymphoma	Positive regulation of mRNA metabolic process →	+0.060	+2.715	.001	.003	3	8
LARGE_INTESTINE	RNA catabolic process →	+0.043	+0.256	<.001	.005	3	8
SKIN	Regulation of synoviocyte proliferation →	-0.344	-1.144	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,180 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by BTK expression — OESOPHAGUS

Explore this box plot interactively →