BTK

Across TCGA cell cohorts, BTK mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible BTK-associated genes across cancer lineages are OR4F6, ASB17, and NPVF. Each is linked with BTK in more than 1 cancer types. Because this analysis shows association rather than direction, both BTK-to-partner and partner-to-BTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F6 grouped by BTK-low versus BTK-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTK→partner) and Y-score (partner→BTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4F6 →	+0.019	+5.321	<.001	.005	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
BREAST	NPVF →	+0.518	+4.196	<.001	.006	3	1
BREAST	LRRC52 →	+0.078	+4.232	<.001	.002	3	1
BREAST	C11orf97 →	+0.141	+4.415	<.001	.001	3	1
LARGE_INTESTINE	CAMP →	+0.378	+3.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR4F6 by BTK expression — CNS

Explore this box plot interactively →