BTG4

Across TCGA patient cohorts, BTG4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTG4-associated genes across cancer lineages are Rad50, ATM, and eIF4E. Each is linked with BTG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTG4-to-partner and partner-to-BTG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by BTG4-low versus BTG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTG4→partner) and Y-score (partner→BTG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.228	-2.115	.031	.019	3	2
UCEC	ATM →	-0.579	-2.115	.003	.019	3	2
UCEC	eIF4E →	+0.192	+3.013	.037	.018	3	1
UCEC	eIF4G →	+0.272	+3.000	.045	.036	3	1
UCEC	JNK2 →	+0.277	+3.026	.001	.018	3	1
UCEC	mTOR_pS2448 →	-0.146	-2.302	.024	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Rad50 by BTG4 expression — UCEC

Explore this box plot interactively →