BTG4

Across TCGA cell cohorts, BTG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,502 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible BTG4-associated GO terms across cancer lineages are Regulation of extrinsic apoptotic signaling pathway via death domain receptors, Negative regulation of calcineurin-mediated signaling, and Regulation of programmed necrotic cell death. Each is linked with BTG4 in more than 8 cancer types. Because this analysis shows association rather than direction, both BTG4-to-partner and partner-to-BTG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of extrinsic apoptotic signaling pathway via death domain receptors grouped by BTG4-low versus BTG4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BTG4→partner) and Y-score (partner→BTG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of extrinsic apoptotic signaling pathway via death domain receptors →	+0.104	+0.095	.001	<.001	3	9
BONE	Negative regulation of calcineurin-mediated signaling →	+0.236	+0.236	<.001	.009	3	8
OVARY	Regulation of programmed necrotic cell death →	+0.068	+0.216	<.001	.001	3	8
BONE	Negative regulation of calcineurin-NFAT signaling cascade →	+0.236	+0.236	<.001	.009	3	8
SKIN	Maintenance of protein localization in organelle →	+0.068	+0.205	<.001	.005	3	8
BLOOD_Lymphoma	Regulation of extrinsic apoptotic signaling pathway →	+0.057	+0.246	<.001	.006	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,502 associations by consensus.

Regulation of extrinsic apoptotic signaling pathway via death domain receptors by BTG4 expression — BREAST

Explore this box plot interactively →