BTG3

Across TCGA patient cohorts, BTG3 mutation is significantly associated with the RNA expression of many other genes, with 1,780 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTG3-associated genes across cancer lineages are RNA5SP21, OR1S2, and RNU4-9P. Each is linked with BTG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTG3-to-partner and partner-to-BTG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP21 grouped by BTG3-low versus BTG3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTG3→partner) and Y-score (partner→BTG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP21 →	+0.400	+4.215	.003	.009	3	2
HNSC	OR1S2 →	+0.050	+5.912	<.001	.002	3	1
HNSC	RNU4-9P →	+0.297	+5.303	.001	.006	3	1
UCEC	RN7SKP290 →	+0.194	+2.773	.004	.004	3	1
UCEC	POM121C →	+0.548	+2.724	<.001	.003	3	1
UCEC	DCP1A →	+0.822	+3.502	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,780 associations by consensus.

RNA5SP21 by BTG3 expression — SKCM

Explore this box plot interactively →