BTG3

Across TCGA patient cohorts, BTG3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTG3-associated genes across cancer lineages are EGFR_pY1068, Heregulin, and INPP4B. Each is linked with BTG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTG3-to-partner and partner-to-BTG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by BTG3-low versus BTG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTG3→partner) and Y-score (partner→BTG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.327	-3.321	.005	.010	3	1
UCEC	Heregulin →	-0.160	-2.459	.005	.019	3	1
UCEC	INPP4B →	-0.297	-3.169	.049	.019	3	1
UCEC	ACVRL1 →	-0.170	-2.439	.007	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-2.571	.009	.011	3	1
UCEC	Myosin-IIa →	+0.194	+3.592	.030	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by BTG3 expression — UCEC

Explore this box plot interactively →