BTG2

Across TCGA patient cohorts, BTG2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTG2-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and ACC1. Each is linked with BTG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTG2-to-partner and partner-to-BTG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BTG2-low versus BTG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTG2→partner) and Y-score (partner→BTG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.813	+2.999	.003	.035	3	2
UCEC	14-3-3_beta →	-0.113	-2.973	.015	.035	3	1
UCEC	ACC1 →	+0.430	+3.013	.011	.018	3	1
UCEC	MEK1 →	+0.503	+3.321	.003	.010	3	1
UCEC	p27_pT157 →	-0.085	-3.420	.001	.005	3	1
UCEC	p70-S6K_pT389 →	-0.214	-3.160	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Caspase-7-cleavedD198 by BTG2 expression — UCEC

Explore this box plot interactively →