BTG1

Across TCGA patient cohorts, BTG1 mutation is significantly associated with the RNA expression of many other genes, with 514 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTG1-associated genes across cancer lineages are NDUFAF5, RRP8, and NABP2. Each is linked with BTG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTG1-to-partner and partner-to-BTG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF5 grouped by BTG1-low versus BTG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTG1→partner) and Y-score (partner→BTG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF5 →	+0.479	+3.222	<.001	.009	3	2
UCEC	RRP8 →	+0.472	+3.595	<.001	.001	3	2
UCEC	NABP2 →	+0.517	+3.606	.001	.001	3	2
UCEC	RNPS1 →	+0.426	+3.617	.006	.001	3	2
UCEC	RNU6-1213P →	+0.276	+4.140	<.001	<.001	3	2
DLBC	NUTM2F →	+0.370	+3.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 514 associations by consensus.

NDUFAF5 by BTG1 expression — UCEC

Explore this box plot interactively →