BTG1

Across TCGA patient cohorts, BTG1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTG1-associated genes across cancer lineages are A-Raf_pS299, FoxM1, and FOXO3a_pS318_S321. Each is linked with BTG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTG1-to-partner and partner-to-BTG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by BTG1-low versus BTG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTG1→partner) and Y-score (partner→BTG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.176	-3.000	.003	.036	3	1
UCEC	FoxM1 →	+0.285	+2.321	.028	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.175	-3.312	.005	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.255	-3.446	.002	.005	3	1
UCEC	Ku80 →	+0.260	+2.335	.028	.020	3	1
UCEC	Notch1 →	+0.163	+3.459	.021	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

A-Raf_pS299 by BTG1 expression — UCEC

Explore this box plot interactively →