BTF3

Across TCGA patient cohorts, BTF3 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTF3-associated genes across cancer lineages are VHL, p62 Lck ligand, and Cyclin-B1. Each is linked with BTF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTF3-to-partner and partner-to-BTF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by BTF3-low versus BTF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTF3→partner) and Y-score (partner→BTF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.320	-3.169	<.001	.019	3	2
UCEC	p62 Lck ligand →	+0.340	+3.009	.046	.019	3	1
UCEC	Cyclin-B1 →	+0.688	+3.321	.019	.010	3	1
UCEC	Notch1 →	+0.240	+3.321	.001	.010	1	1
UCEC	Caspase-8 →	-0.322	-3.321	.014	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

VHL by BTF3 expression — UCEC

Explore this box plot interactively →