BTD

Across TCGA patient cohorts, BTD mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTD-associated genes across cancer lineages are GAPDH, PCNA, and Src_pY416. Each is linked with BTD in more than 1 cancer types. Because this analysis shows association rather than direction, both BTD-to-partner and partner-to-BTD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by BTD-low versus BTD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTD→partner) and Y-score (partner→BTD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.459	+2.459	.025	.019	3	2
UCEC	PCNA →	+0.231	+2.700	.005	.005	3	2
UCEC	Src_pY416 →	-0.212	-2.074	.021	.005	3	2
UCEC	eEF2 →	+0.383	+2.087	.005	.005	3	1
UCEC	EGFR_pY1068 →	-0.325	-2.584	<.001	.001	3	1
UCEC	ERK2 →	+0.173	+1.678	.019	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GAPDH by BTD expression — UCEC

Explore this box plot interactively →