Across TCGA patient cohorts, BTBD8 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTBD8-associated genes across cancer lineages are FASN, IGFBP2, and MEK1. Each is linked with BTBD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD8-to-partner and partner-to-BTBD8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD8→partner) and Y-score (partner→BTBD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.434	+3.169	.011	.019	3	1
UCEC	IGFBP2 →	-0.812	-2.999	.004	.035	3	1
UCEC	MEK1 →	+0.467	+2.807	.003	.003	3	1
UCEC	MSH2 →	-0.229	-2.973	.023	.035	3	1
UCEC	p62 Lck ligand →	+0.550	+2.115	<.001	.019	3	1
UCEC	Tuberin →	+0.346	+2.807	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

BTBD8 survival (RNA) · tumor vs normal (RNA) · all BTBD8 data types