BTBD3

Across TCGA patient cohorts, BTBD3 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTBD3-associated genes across cancer lineages are Cyclin-E2, FoxM1, and INPP4B. Each is linked with BTBD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BTBD3-to-partner and partner-to-BTBD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by BTBD3-low versus BTBD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD3→partner) and Y-score (partner→BTBD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.132	+1.523	.013	.008	3	3
UCEC	FoxM1 →	+0.189	+2.378	.022	<.001	3	2
UCEC	INPP4B →	-0.322	-2.584	.001	<.001	3	2
UCEC	Tuberin_pT1462 →	+0.216	+1.584	.003	.032	3	2
UCEC	Caspase-7-cleavedD198 →	+0.568	+3.189	.002	<.001	3	2
UCEC	Caspase-8 →	-0.266	-2.058	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Cyclin-E2 by BTBD3 expression — UCEC

Explore this box plot interactively →