BTBD3

Across TCGA cell cohorts, BTBD3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BTBD3-associated genes across cancer lineages are GHRH, UCMA, and ACKR1. Each is linked with BTBD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD3-to-partner and partner-to-BTBD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by BTBD3-low versus BTBD3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD3→partner) and Y-score (partner→BTBD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
LARGE_INTESTINE	UCMA →	+0.017	+3.632	<.001	.003	3	1
LARGE_INTESTINE	ACKR1 →	+0.047	+4.032	<.001	.004	3	1
LARGE_INTESTINE	SCYGR4 →	+0.038	+3.994	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GHRH by BTBD3 expression — OESOPHAGUS

Explore this box plot interactively →