BTBD2

Across TCGA patient cohorts, BTBD2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTBD2-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Met_pY1235, and mTOR_pS2448. Each is linked with BTBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD2-to-partner and partner-to-BTBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BTBD2-low versus BTBD2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD2→partner) and Y-score (partner→BTBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.849	+2.824	.022	.034	3	2
COAD	c-Met_pY1235 →	+0.097	+2.212	.042	.033	3	2
UCEC	mTOR_pS2448 →	-0.161	-2.986	.016	.035	3	2
UCEC	PCNA →	+0.423	+3.700	<.001	.001	3	2
UCEC	Annexin-1 →	+0.675	+3.189	.004	.010	3	2
COAD	PRDX1 →	+0.262	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Caspase-7-cleavedD198 by BTBD2 expression — COAD

Explore this box plot interactively →