BTBD2

Across TCGA cell cohorts, BTBD2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BTBD2-associated genes across cancer lineages are GZMK, OR2M3, and APOL5. Each is linked with BTBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD2-to-partner and partner-to-BTBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by BTBD2-low versus BTBD2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD2→partner) and Y-score (partner→BTBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GZMK →	+0.056	+5.169	<.001	.005	3	1
BREAST	OR2M3 →	+0.006	+5.169	<.001	.005	3	1
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	1
BLOOD_Leukemia	CLDN8 →	+0.013	+3.234	<.001	.008	3	1
BLOOD_Leukemia	TACR3 →	+0.023	+3.475	<.001	.006	3	1
BLOOD_Leukemia	SRY →	+0.028	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GZMK by BTBD2 expression — BREAST

Explore this box plot interactively →