BTBD18

Across TCGA patient cohorts, BTBD18 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTBD18-associated genes across cancer lineages are FOXO3a, INPP4B, and JNK2. Each is linked with BTBD18 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD18-to-partner and partner-to-BTBD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by BTBD18-low versus BTBD18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD18→partner) and Y-score (partner→BTBD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.103	+2.335	.043	.020	3	1
UCEC	INPP4B →	-0.345	-3.169	.033	.019	3	1
UCEC	JNK2 →	+0.423	+3.026	<.001	.018	3	1
UCEC	Ku80 →	+0.317	+3.331	.007	.005	3	1
UCEC	MEK1 →	+0.466	+3.169	.011	.019	3	1
UCEC	ATM →	-0.663	-2.321	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

FOXO3a by BTBD18 expression — UCEC

Explore this box plot interactively →