BTBD18

Across TCGA cell cohorts, BTBD18 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BTBD18-associated genes across cancer lineages are AADACL3, LGALS16, and HNRNPCL4. Each is linked with BTBD18 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD18-to-partner and partner-to-BTBD18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AADACL3 grouped by BTBD18-low versus BTBD18-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD18→partner) and Y-score (partner→BTBD18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AADACL3 →	+0.024	+5.169	<.001	<.001	3	1
LUNG_SCLC	LGALS16 →	+0.148	+4.817	<.001	.001	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.049	+3.793	.004	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

AADACL3 by BTBD18 expression — LUNG_SCLC

Explore this box plot interactively →