BTBD16

Across TCGA patient cohorts, BTBD16 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BTBD16-associated genes across cancer lineages are p62 Lck ligand, PCNA, and Caspase-7-cleavedD198. Each is linked with BTBD16 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD16-to-partner and partner-to-BTBD16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by BTBD16-low versus BTBD16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD16→partner) and Y-score (partner→BTBD16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.411	+2.817	<.001	.001	3	2
UCEC	PCNA →	+0.212	+2.115	.008	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.473	+2.479	.033	.010	3	2
SKCM	GAPDH →	+0.684	+2.000	.009	.031	3	1
UCEC	14-3-3_beta →	-0.102	-2.432	.007	.018	3	1
UCEC	EGFR_pY1068 →	-0.199	-1.415	.034	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p62 Lck ligand by BTBD16 expression — UCEC

Explore this box plot interactively →