BTBD10

Across TCGA pan-cancer cohorts, BTBD10 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of BTBD10’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BTBD10 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types BTBD10 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, LUAD, and CCRCC are the cancer types where BTBD10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BTBD10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−0.459	<.001	8	view →
LUAD	All	III,IV	+0.465	.001	6	view →
CCRCC	Male	III,IV	+0.288	.011	3	view →
LSCC	All	All	+0.074	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

BTBD10–HNSC

Open the HNSC breakdown →