BTBD1

Across TCGA cell cohorts, BTBD1 mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BTBD1-associated genes across cancer lineages are CFHR2, ZIC3, and TMEM244. Each is linked with BTBD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BTBD1-to-partner and partner-to-BTBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by BTBD1-low versus BTBD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD1→partner) and Y-score (partner→BTBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	2
BLOOD_Leukemia	ZIC3 →	+0.019	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TMEM244 →	+0.354	+4.551	<.001	.004	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.016	+4.551	<.001	.004	3	1
LARGE_INTESTINE	P3H3 →	+1.859	+3.212	.001	.006	3	1
LARGE_INTESTINE	KCNIP3 →	+1.127	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

CFHR2 by BTBD1 expression — BLOOD_Leukemia

Explore this box plot interactively →