BTBD1

Across TCGA cell cohorts, BTBD1 mutation is significantly associated with the mutation status of many other genes, with 3,261 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BTBD1-associated genes across cancer lineages are CUL1, CLCN7, and TRPS1. Each is linked with BTBD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both BTBD1-to-partner and partner-to-BTBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CUL1 grouped by BTBD1-low versus BTBD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BTBD1→partner) and Y-score (partner→BTBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CUL1 →	+4.479	+5.635	<.001	<.001	1	4
BLOOD_Leukemia	CLCN7 →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	TRPS1 →	+2.672	+4.225	.008	.008	1	3
BLOOD_Leukemia	MLH3 →	+3.479	+4.932	.002	.002	1	3
BLOOD_Leukemia	ABR →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	RNF169 →	+5.479	+6.145	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,261 associations by consensus.

CUL1 by BTBD1 expression — BLOOD_Leukemia

Explore this box plot interactively →