Across TCGA patient cohorts, BSX mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BSX-associated genes across cancer lineages are ER-alpha, Cyclin-B1, and Tuberin_pT1462. Each is linked with BSX in more than 1 cancer types. Because this analysis shows association rather than direction, both BSX-to-partner and partner-to-BSX results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSX→partner) and Y-score (partner→BSX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-1.027	-3.000	.030	.037	3	2
UCEC	Cyclin-B1 →	+0.685	+3.000	.035	.037	3	2
UCEC	Tuberin_pT1462 →	+0.336	+3.000	.011	.037	3	1
UCEC	Rad50 →	-0.319	-3.000	.022	.037	2	1
UCEC	Notch1 →	+0.276	+3.000	<.001	.037	1	1
UCEC	PR →	-0.302	-3.000	.037	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

BSX survival (RNA) · tumor vs normal (RNA) · all BSX data types