BST2

Across TCGA pan-cancer cohorts, BST2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BST2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BST2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BST2 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where BST2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BST2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+4.433	<.001	11	view →
KIRC	Male	IV	+1.806	<.001	11	view →
STAD	All	II,III,IV	+1.454	<.001	8	view →
LUSC	Male	III,IV	−2.635	<.001	7	view →
BLCA	All	All	+1.072	.013	6	view →
BRCA	All	II,III,IV	+0.725	<.001	6	view →
KICH	Female	All	−1.891	<.001	5	view →
COAD	Female	II,III,IV	+1.185	.001	5	view →
ESCA	All	All	+1.961	.018	2	view →
PRAD	All	All	−0.980	<.001	2	view →
KIRP	All	All	−0.840	.013	2	view →
READ	Female	All	−1.195	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BST2–HNSC

Open the HNSC breakdown →