BSPRY

Across TCGA patient cohorts, BSPRY mutation is significantly associated with the RNA expression of many other genes, with 1,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BSPRY-associated genes across cancer lineages are SNORD30, PEX13, and GATD1. Each is linked with BSPRY in more than 1 cancer types. Because this analysis shows association rather than direction, both BSPRY-to-partner and partner-to-BSPRY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD30 grouped by BSPRY-low versus BSPRY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSPRY→partner) and Y-score (partner→BSPRY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD30 →	+1.243	+3.126	<.001	.001	3	2
UCEC	PEX13 →	+0.593	+3.721	.001	<.001	3	2
UCEC	GATD1 →	+0.687	+3.617	<.001	.001	3	2
UCEC	ALDH18A1 →	+0.518	+3.202	.009	.009	3	2
UCEC	PMS2P7 →	+0.154	+3.202	.006	.009	3	2
UCEC	MCPH1-AS1 →	+0.434	+3.467	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,120 associations by consensus.

SNORD30 by BSPRY expression — UCEC

Explore this box plot interactively →