BSPRY

Across TCGA cell cohorts, BSPRY mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BSPRY-associated genes across cancer lineages are ASCL3, OR2D3, and TAS2R41. Each is linked with BSPRY in more than 1 cancer types. Because this analysis shows association rather than direction, both BSPRY-to-partner and partner-to-BSPRY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASCL3 grouped by BSPRY-low versus BSPRY-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSPRY→partner) and Y-score (partner→BSPRY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASCL3 →	+0.207	+3.726	<.001	.004	3	1
LARGE_INTESTINE	OR2D3 →	+0.022	+3.510	.001	.003	3	1
LARGE_INTESTINE	TAS2R41 →	+0.028	+3.345	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ASCL3 by BSPRY expression — LARGE_INTESTINE

Explore this box plot interactively →