BSG

Across TCGA pan-cancer cohorts, BSG RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of BSG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BSG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BSG is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where BSG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BSG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.936	<.001	12	view →
KIRP	Female	II,III,IV	+0.702	<.001	11	view →
LIHC	Female	II,III,IV	+2.032	<.001	9	view →
KICH	Female	All	+1.176	<.001	9	view →
COAD	Female	All	−0.775	<.001	9	view →
STAD	Male	II,III,IV	+1.070	<.001	6	view →
UCEC	All	All	+0.730	<.001	6	view →
BRCA	All	III,IV	+0.542	<.001	6	view →
LUSC	All	II,III,IV	+0.435	<.001	6	view →
CHOL	Male	All	+2.585	<.001	5	view →
LUAD	All	III,IV	+0.317	.003	4	view →
ESCA	Female	All	+0.686	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

BSG–HNSC

Open the HNSC breakdown →