BSDC1

Across TCGA cell cohorts, BSDC1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BSDC1-associated genes across cancer lineages are SPATA48, GPR101, and DYDC1. Each is linked with BSDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BSDC1-to-partner and partner-to-BSDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by BSDC1-low versus BSDC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSDC1→partner) and Y-score (partner→BSDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPATA48 →	+0.013	+5.662	<.001	.002	3	2
LUNG_NSCLC_LUAD	GPR101 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	DYDC1 →	+0.041	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	LRIT2 →	+0.018	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR1D4 →	+0.062	+5.662	<.001	.002	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SPATA48 by BSDC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →