BSCL2

Across TCGA patient cohorts, BSCL2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BSCL2-associated genes across cancer lineages are MEK1, Notch1, and TIGAR. Each is linked with BSCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BSCL2-to-partner and partner-to-BSCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by BSCL2-low versus BSCL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSCL2→partner) and Y-score (partner→BSCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.524	+3.169	.009	.019	3	1
UCEC	Notch1 →	+0.198	+2.817	.010	.036	3	1
UCEC	TIGAR →	+0.219	+3.196	.008	.010	3	1
UCEC	EGFR_pY1068 →	-0.320	-3.169	.020	.020	1	1
UCEC	p38-MAPK_pT180_Y182 →	-0.805	-3.156	.001	.020	1	1
UCEC	PCNA →	+0.245	+3.169	.038	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by BSCL2 expression — UCEC

Explore this box plot interactively →