BSCL2

Across TCGA cell cohorts, BSCL2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BSCL2-associated genes across cancer lineages are MDGA2, BPIFB6, and OR52A5. Each is linked with BSCL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BSCL2-to-partner and partner-to-BSCL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDGA2 grouped by BSCL2-low versus BSCL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BSCL2→partner) and Y-score (partner→BSCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MDGA2 →	+0.200	+3.854	<.001	.006	3	1
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR52A5 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	NPAP1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	LCE4A →	+0.056	+4.437	<.001	.004	3	1
LARGE_INTESTINE	IFNA14 →	+0.028	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MDGA2 by BSCL2 expression — LARGE_INTESTINE

Explore this box plot interactively →