BRWD3

Across TCGA pan-cancer cohorts, BRWD3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated BRWD3 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher BRWD3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BRWD3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD and PDAC are the cancer types where BRWD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.762	0.507	.043	2	view →
PDAC	OS	Tertile	II,III,IV	1.000	0.878	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

BRWD3–LUAD (OS)

Open the LUAD breakdown →