BRWD3

Across TCGA patient cohorts, BRWD3 mutation is significantly associated with the RNA expression of many other genes, with 6,362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRWD3-associated genes across cancer lineages are SKA1, EME1, and PCGF6. Each is linked with BRWD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRWD3-to-partner and partner-to-BRWD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by BRWD3-low versus BRWD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRWD3→partner) and Y-score (partner→BRWD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.729	+2.180	<.001	<.001	3	3
UCEC	EME1 →	+0.555	+2.038	<.001	<.001	3	3
UCEC	PCGF6 →	+0.282	+0.934	.005	.008	3	3
UCEC	MPV17L →	-0.485	-1.295	.001	<.001	3	3
UCEC	NAE1 →	+0.479	+1.527	<.001	<.001	3	3
LUAD	SPC24 →	+0.632	+2.333	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,362 associations by consensus.

SKA1 by BRWD3 expression — UCEC

Explore this box plot interactively →