BRWD3

Across TCGA patient cohorts, BRWD3 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRWD3-associated genes across cancer lineages are CD20, VHL, and c-Met_pY1235. Each is linked with BRWD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRWD3-to-partner and partner-to-BRWD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD20 grouped by BRWD3-low versus BRWD3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRWD3→partner) and Y-score (partner→BRWD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD20 →	+0.188	+2.321	.020	.037	3	4
COAD	VHL →	-0.690	-1.691	.014	.043	3	4
UCEC	c-Met_pY1235 →	+0.046	+1.009	.012	.025	3	4
BRCA	p70-S6K_pT389 →	+0.281	+2.833	.010	.035	3	3
LUAD	FoxM1 →	+0.311	+3.597	.004	.001	3	3
LUAD	4E-BP1 →	+0.319	+2.472	.012	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

CD20 by BRWD3 expression — BRCA

Explore this box plot interactively →